Platelet Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Mitigate Methotrexate-Induced Nephrotoxicity in Rat via Nrf2/Pparγ/HO-1 and NF-Κb/Keap1/Caspase-3 Signaling Pathways: Oxidative Stress and Apoptosis Interplay.
Farooq Ahmed WaniMahrous A IbrahimShimaa H AmeenAmira E FarageZinab Abd-Elhady AliKhaldoon SalehMedhat M FaragMohammed U SayeedMuhannad A Y AlruwailiAbdulsalam H F AlruwailiAhmad Z A AljaredRania A GalhomPublished in: Toxics (2023)
repeated administration of low-dose MTX resulted in massive renal tissue toxicity and deterioration of renal function in rats which proved to be attenuated by PRP and AD-MSCs through their anti-inflammatory, anti-apoptotic and anti-fibrotic properties.
Keyphrases
- oxidative stress
- platelet rich plasma
- diabetic rats
- mesenchymal stem cells
- induced apoptosis
- anti inflammatory
- low dose
- cell death
- signaling pathway
- high dose
- umbilical cord
- ischemia reperfusion injury
- pi k akt
- dna damage
- cell cycle arrest
- bone marrow
- drug induced
- high glucose
- type diabetes
- idiopathic pulmonary fibrosis
- heat shock
- systemic sclerosis
- stem cells
- skeletal muscle
- protein protein
- fatty acid
- heat shock protein
- endothelial cells