Exercise in newly diagnosed patients with multiple myeloma: A randomized controlled trial of effects on physical function, physical activity, lean body mass, bone mineral density, pain, and quality of life.
Rikke Faebo LarsenMary JardenLisbeth Rosenbek MinetUlf Christian FrølundAnne Pernille HermannLeif BreumSören MöllerNiels AbildgaardPublished in: European journal of haematology (2024)
Reduced physical function caused by bone destruction, pain, anemia, infections, and weight loss is common in multiple myeloma (MM). Myeloma bone disease challenges physical exercise. Knowledge on the effects and safety of physical exercise in newly diagnosed patients with MM is limited. In a randomized, controlled trial, we studied the effect of a 10-week individualized physical exercise program on physical function, physical activity, lean body mass (LBM), bone mineral density (BMD), quality of life (QoL), and pain in patients newly diagnosed with MM. Lytic bone disease was assessed, and exercise was adjusted accordingly. Primary outcome: knee extension strength. Secondary outcomes: Six-Minute-Walk-Test, 30-s Sit-to-Stand-Test (SST), grip strength, level of physical activity, LBM, BMD, QoL, and pain. Measurements were conducted pre- and post-intervention, and after 6 and 12 months. We included 100 patients, 86 were evaluable; 44 in the intervention group (IG) and 42 in the control group (CG). No statistically significant differences between groups were observed. Knee extension strength declined in the IG (p = .02). SST, aerobic capacity, and global QoL improved in both groups. Pain decreased consistently in the IG regardless of pain outcome. No significant safety concerns of physical exercise in newly diagnosed patients with MM were observed.
Keyphrases
- newly diagnosed
- bone mineral density
- physical activity
- chronic pain
- postmenopausal women
- body composition
- pain management
- neuropathic pain
- multiple myeloma
- randomized controlled trial
- weight loss
- total knee arthroplasty
- high intensity
- body mass index
- spinal cord
- chronic kidney disease
- knee osteoarthritis
- ejection fraction
- spinal cord injury
- roux en y gastric bypass
- bariatric surgery
- depressive symptoms
- skeletal muscle
- patient reported outcomes
- bone loss
- patient reported