Tiragolumab (Anti-TIGIT) in SCLC: Skyscraper-02, a Towering Inferno.
Danielle BrazelSai-Hong Ignatius OuMisako NagasakaPublished in: Lung Cancer (Auckland, N.Z.) (2023)
Small cell lung cancer (SCLC) is characterized by rapid progression and poor prognosis. Although the phase II CITYSCAPE-02 trial found objective response rate (ORR) and progression-free survival (PFS) of non-small cell lung cancer (NSCLC) patients improved when tiragolumab was added to atezolizumab and chemotherapy, the phase III SKYSCRAPER-02 failed to find PFS or OS benefit in patients with SCLC. Atezolizumab was the first immunotherapy to show survival benefit in extensive SCLC based on the phase III IMpower133 study. Given that immunotherapy has become the standard of care for SCLC patients, further research is needed into ways to augment the immune system to better treat these patients.
Keyphrases
- phase iii
- phase ii
- small cell lung cancer
- end stage renal disease
- clinical trial
- poor prognosis
- open label
- newly diagnosed
- chronic kidney disease
- healthcare
- prognostic factors
- peritoneal dialysis
- free survival
- long non coding rna
- patient reported outcomes
- advanced non small cell lung cancer
- chronic pain
- quantum dots
- rectal cancer