Decreased serum concentrations of anti-seizure medications in children with drug resistant epilepsy following treatment with ketogenic diet.
Sigrid PedersenMagnhild KvernelandKnut RudiKristina GervinCecilie Johannessen LandmarkPer Ole IversenKaja Kristine SelmerPublished in: Epilepsia open (2023)
We identified a significant decrease in the serum concentrations of clobazam, desmethylclobazam, and lamotrigine following a 12-week ketogenic diet intervention in children with drug resistant epilepsy. An unintended decrease in the serum concentrations of ASMs may render the patient prone to seizures. Measurements of ASM serum concentrations might be useful in patients on a ketogenic diet, especially in patients with lack of efficacy of the dietary treatment.
Keyphrases
- drug resistant
- multidrug resistant
- acinetobacter baumannii
- physical activity
- weight loss
- young adults
- end stage renal disease
- ejection fraction
- randomized controlled trial
- newly diagnosed
- chronic kidney disease
- clinical trial
- pseudomonas aeruginosa
- case report
- patient reported outcomes
- temporal lobe epilepsy
- patient reported