Stroke Alters the Function of Enteric Neurons to Impair Smooth Muscle Relaxation and Dysregulates Gut Transit.
Kathryn Prame KumarJenny L WilsonHuynh NguyenLiam D McKayShu Wen WenTara SepehrizadehMichael de VeerPradeep RajasekharSimona E CarboneMichael J HickeyDaniel P PooleConnie H Y WongPublished in: Journal of the American Heart Association (2024)
Our findings demonstrate that activation of the sympathetic nervous system after stroke is associated with reduced neuronal nitric oxide synthase expression in myenteric neurons, resulting in impaired smooth muscle relaxation and dysregulation of gut transit.