Cannabidiol regulates the expression of hypothalamus-pituitary-adrenal axis-related genes in response to acute restraint stress.
Adrián Viudez-MartínezMaría S García-GutiérrezJorge ManzanaresPublished in: Journal of psychopharmacology (Oxford, England) (2018)
Taken together, these data suggest the ability of cannabidiol to regulate acute stress hypothalamus-pituitary-adrenal axis activation might be explained, at least in part, by its action on 5-HTR1A receptors.