Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium.
Tae Hoon KimSteven L YoungTsutomu SasakiJeffrey L DeatonDavid P SchammelWilder Alberto Palomino AJae-Wook JeongBruce A LesseyPublished in: The Journal of clinical endocrinology and metabolism (2021)
SIRT1 expression and progesterone resistance appears to play -roles in normal endometrial functions. Aberrant SIRT1 expression contributes to progesterone resistance and may participate in the pathophysiology of endometriosis. SIRT1 is a novel and targetable protein for the diagnosis as well as treatment of endometriosis and the associated infertility seen in this disease.