Copper-Catalyzed Coupling of Acyl Chlorides with gem-Difluorinated Organozinc Reagents via Acyl Dithiocarbamates.
Salavat S AshirbaevVitalij V LevinMarina I StruchkovaAlexander D DilmanPublished in: The Journal of organic chemistry (2017)
A cross-coupling of acyl chlorides with gem-difluorinated organozinc reagents affording difluorinated ketones is described. In the reaction, acyl chlorides are first treated with potassium dithiocarbamate to generate S-acyl dithiocarbamates, which couple with organozincs in the presence of a copper(I) catalyst.