Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations).
Haider MahdiNavid HafezDeborah B DoroshowDavendra SohalVickie KeedyKhanh T DoPatricia LoRussoJuliane JürgensmeierManuel AvedissianJeffrey S SklarColin GloverBrunella FelicettiEmma DeanPeter G S MortimerGeoffrey I ShapiroJoseph Paul EderPublished in: JCO precision oncology (2021)
Olaparib with ceralasertib demonstrated preliminary activity in ATM-mutated tumors and in PARP inhibitor-resistant BRCA1/2-mutated HGSOC. These data warrant additional studies to further confirm activity in these settings.