Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy.

Xue-Bin Ran Ling-Wen Ding Qiao-Yang Sun Henry Yang Jonathan W Said Zhentang Lao Vikas Madan Pushkar Dakle Jin-Fen Xiao Xinyi Loh Ying Li Liang Xu Xiao-Qiang Xiang Ling-Zhi Wang Boon Cher Goh De-Chen Lin Wee-Joo Chng Soo Yong Tan Sudhakar Jha H Phillip Koeffler

Published in: Cancer research (2023)

Targeting XRN1 activates an intracellular innate immune response mediated by RNA-sensing signaling and potentiates cancer immunotherapy efficacy, suggesting inhibition of RNA decay machinery as a novel strategy for cancer treatment.

Keyphrases

immune response
cancer therapy
nucleic acid
dendritic cells
toll like receptor