The levels of the serine protease HTRA1 in cerebrospinal fluid correlate with progression and disability in multiple sclerosis.
Simone HjæresenTobias SejbækMarcus AxelssonHelle Vinsløv-JensenSif Kløvedal MortensenGorm Pihl-JensenLenka NovakovaJulie Damgaard Rosgaard ChristensenChristian Bonde PedersenBo HalleFrantz Rom PoulsenJette Lautrup FrederiksenMengliang ZhangEirkiur BenedikzJan LyckeZsolt IllesÅsa Fex SvenningsenPublished in: Journal of neurology (2021)
HTRA1 is a promising CSF biomarker for MS correlating with disease- and disability progression. Most cell species of the normal and diseased CNS express HTRA1 and the expression pattern could reflect pathological processes involved in MS pathogenesis.