Linagliptin ameliorated cardiac fibrosis and restored cardiomyocyte structure in diabetic mice associated with the suppression of necroptosis.
Juthi AdhikariTaro HiraiEmi KawakitaKunimitsu IwaiDaisuke KoyaKeizo KanasakiPublished in: Journal of diabetes investigation (2023)
Linagliptin showed excellent heart protection in mice with streptozotocin-induced diabetes associated with alterations in human disease-relevant hub genes. Further investigation is required to determine why DPP-4 inhibitors do not show similar superior organ-protective effects in the clinical setting.
Keyphrases
- diabetic rats
- high glucose
- endothelial cells
- bioinformatics analysis
- oxidative stress
- type diabetes
- cardiovascular disease
- high fat diet
- heart failure
- left ventricular
- induced pluripotent stem cells
- genome wide
- high fat diet induced
- pluripotent stem cells
- glycemic control
- atrial fibrillation
- angiotensin ii
- diabetic nephropathy
- network analysis
- genome wide identification
- insulin resistance
- liver fibrosis