Effects of Methylprednisolone in the Treatment of Spinal Cord Injuries by Evaluation of microRNA-21: An Experimental Study.
Anas AbdallahAbdurrahim TekinMustafa Namik OztanirSeda SüsgünAyşegül Yabacı Takİrfan ÇınarEngin CanSadık TokarFahri AkbasMehmet Hakan SeyithanogluPublished in: Journal of neurological surgery. Part A, Central European neurosurgery (2022)
miR-21 supports the beneficial aspects of the body's healing mechanisms following SCI. In the acute phase, the use of methylprednisolone increases miR-21 expression in the early period of trauma. Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.