Considerations for improved performance of competition association assays analysed with the Motulsky-Mahan's "kinetics of competitive binding" model.

Victoria Georgi Alexey DubrovskiyStephan SteigeleAmaury E Fernández-Montalván

Published in: British journal of pharmacology (2019)

Our data advances our comprehension of the Motulsky-Mahan kinetics of competitive binding models and provides experimental design recommendations, data analysis tools, and general guidelines for its practical application to in vitro pharmacology and drug screening.

Keyphrases

data analysis
clinical practice
dna binding
binding protein
high throughput
electronic health record
aqueous solution
emergency department
big data
transcription factor
machine learning
deep learning