Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells.
L AbsilF JournéD LarsimontJ J BodyL TafforeauDenis NonclercqPublished in: BMC cancer (2020)
Our experimental results point to a relationship between the expression of FXR in breast cancer cells and the propensity of these tumor cells to develop bone metastases. FXR induces the expression of RUNX2 which itself causes the synthesis of bone proteins by tumor cells.