The glucose tolerance test in mice: Sex, drugs and protocol.

Matilda R KennardManasi Nandi Sarah J Chapple Aileen J F King

Published in: Diabetes, obesity & metabolism (2022)

Variations in GTT protocol have profound effects on glucose homeostasis. Protocol refinement and/or the use of females still allows for detection of drug effects, providing evidence that more severe phenotypes are not an essential prerequisite when characterizing/validating new drugs.

Keyphrases

randomized controlled trial
drug induced
emergency department
blood glucose
autism spectrum disorder
high fat diet induced
loop mediated isothermal amplification
weight loss
wild type
sensitive detection