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Total neoadjuvant therapy versus standard neoadjuvant treatment strategies for the management of locally advanced rectal cancer: network meta-analysis of randomized clinical trials.

Mark DonnellyOdhrán K RyanÉanna J RyanBen CreavinMary O'ReillyRay McDermottRory KennellyAnn HanlySeán T MartinDes C Winter
Published in: The British journal of surgery (2023)
This study provides further evidence that TNT has improved survival and recurrence benefits compared with current standards of care, and may increase the number of patients suitable for organ preservation, without negatively influencing treatment toxicity or compliance.
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