Total neoadjuvant therapy versus standard neoadjuvant treatment strategies for the management of locally advanced rectal cancer: network meta-analysis of randomized clinical trials.
Mark DonnellyOdhrán K RyanÉanna J RyanBen CreavinMary O'ReillyRay McDermottRory KennellyAnn HanlySeán T MartinDes C WinterPublished in: The British journal of surgery (2023)
This study provides further evidence that TNT has improved survival and recurrence benefits compared with current standards of care, and may increase the number of patients suitable for organ preservation, without negatively influencing treatment toxicity or compliance.
Keyphrases
- rectal cancer
- locally advanced
- neoadjuvant chemotherapy
- systematic review
- end stage renal disease
- squamous cell carcinoma
- phase ii study
- ejection fraction
- radiation therapy
- chronic kidney disease
- healthcare
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- oxidative stress
- palliative care
- clinical trial
- meta analyses
- stem cells
- patient reported outcomes
- randomized controlled trial
- mesenchymal stem cells
- bone marrow
- pain management