Circulating Metabolome and White Matter Hyperintensities in Women and Men.
Eeva SlizJean ShinShahzad AhmadDylan M WilliamsStefan FrenzelFriederike GaußSarah E HarrisAnn-Kristin HenningMaria Del Carmen Valdés-HernándezYi-Han HuBeatriz JiménezMuralidharan SargurupremrajCarole Helene SudreRuiqi WangKatharina WittfeldQiong YangJoanna Marguerite WardlawHenry VölzkeMeike W VernooijJonathan M SchottMarcus RichardsPetroula ProitsiMatthias NauckMatthew R LewisLenore J LaunerNorbert HostenHans J GrabeMohsen GhanbariIan J DearySimon R CoxNishi ChaturvediJosephine BarnesJerome I RotterStephanie DebetteMohammad Arfan IkramMyriam FornageTomas PausSudha SeshadriZdenka Pausovanull nullPublished in: Circulation (2022)
Circulating metabolomic measures, including multiple lipid measures (eg, lysophosphatidylcholines, hydroxysphingomyelins, low-density lipoprotein size and composition) and nonlipid metabolites (eg, hydroxyphenylpyruvate, glucuronate), associate with WMH in a general population of middle-aged and older adults. Some metabolomic measures show marked sex specificities and explain a sizable proportion of WMH variance.