MRI Radiogenomics in Precision Oncology: New Diagnosis and Treatment Method.
Xiao-Xia YinMingyong GaoWei WangYanchun ZhangPublished in: Computational intelligence and neuroscience (2022)
Precision medicine for cancer affords a new way for the most accurate and effective treatment to each individual cancer. Given the high time-evolving intertumor and intratumor heterogeneity features of personal medicine, there are still several obstacles hindering its diagnosis and treatment in clinical practice regardless of extensive exploration on it over the past years. This paper is to investigate radiogenomics methods in the literature for precision medicine for cancer focusing on the heterogeneity analysis of tumors. Based on integrative analysis of multimodal (parametric) imaging and molecular data in bulk tumors, a comprehensive analysis and discussion involving the characterization of tumor heterogeneity in imaging and molecular expression are conducted. These investigations are intended to (i) fully excavate the multidimensional spatial, temporal, and semantic related information regarding high-dimensional breast magnetic resonance imaging data, with integration of the highly specific structured data of genomics and combination of the diagnosis and cognitive process of doctors, and (ii) establish a radiogenomics data representation model based on multidimensional consistency analysis with multilevel spatial-temporal correlations.
Keyphrases
- papillary thyroid
- magnetic resonance imaging
- electronic health record
- single cell
- high resolution
- big data
- squamous cell
- clinical practice
- systematic review
- poor prognosis
- palliative care
- computed tomography
- childhood cancer
- lymph node metastasis
- data analysis
- mass spectrometry
- magnetic resonance
- photodynamic therapy
- social media
- pain management
- smoking cessation
- binding protein
- diffusion weighted imaging
- network analysis