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Oxyberberine sensitizes liver cancer cells to sorafenib via inhibiting NOTCH1-USP7-c-Myc pathway.

Liangbo SunMeng HeFeng LiDi WuPing ZhengCong ZhangYang LiuDong LiuMeihua ShanMingzhen YangYuanhang MaJiqin LianHaojun Xiong
Published in: Hepatology communications (2024)
These results indicate that OBB enhances the sensitivity of liver cancer cells to sorafenib through inhibiting notch homolog 1-USP7-c-Myc signaling pathway, which potentially provides a novel therapeutic strategy for liver cancer to improve the effectiveness of sorafenib.
Keyphrases
  • signaling pathway
  • induced apoptosis
  • pi k akt
  • cell proliferation
  • randomized controlled trial
  • epithelial mesenchymal transition
  • systematic review
  • oxidative stress
  • endoplasmic reticulum stress