Oxyberberine sensitizes liver cancer cells to sorafenib via inhibiting NOTCH1-USP7-c-Myc pathway.

Liangbo SunMeng HeFeng LiDi WuPing ZhengCong ZhangYang LiuDong LiuMeihua ShanMingzhen YangYuanhang MaJiqin LianHaojun Xiong

Published in: Hepatology communications (2024)

These results indicate that OBB enhances the sensitivity of liver cancer cells to sorafenib through inhibiting notch homolog 1-USP7-c-Myc signaling pathway, which potentially provides a novel therapeutic strategy for liver cancer to improve the effectiveness of sorafenib.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell proliferation
randomized controlled trial
epithelial mesenchymal transition
systematic review
oxidative stress
endoplasmic reticulum stress