Human genomic data have different statistical properties than the data of randomised controlled trials.
Mirjam J BorgerFranz J WeissingEva BoonPublished in: The Behavioral and brain sciences (2023)
Madole & Harden argue that the Mendelian reshuffling of genes and genomes is analogous to randomised controlled trials. We are not convinced by their arguments. First, their recipe for meeting the demands on randomised experiments is inherently inconsistent. Second, disequilibrium across chromosomes conflicts with their assumption of statistical independence. Third, the genome-wide association study (GWAS) method has many pitfalls, including low repeatability.
Keyphrases
- genome wide association study
- electronic health record
- endothelial cells
- clinical trial
- big data
- open label
- genome wide
- double blind
- study protocol
- copy number
- induced pluripotent stem cells
- machine learning
- gene expression
- pluripotent stem cells
- placebo controlled
- artificial intelligence
- transcription factor
- bioinformatics analysis
- deep learning
- genome wide analysis