Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation.
Lin XiaWeihong GuMingyi ZhangYa-Nan ChangKui ChenXue BaiLai YuJuan LiShan LiGengmei XingPublished in: Particle and fibre toxicology (2016)
30 nm Ps nanoparticles induced formation of LVLS, blocked the vesicle transport in endocytic system and the distributions of regular proteins required in cytokinesis which led to binucleated cells of macrophages. Markedly raised binucleated rate was also observed in human lung adenocarcinoma epithelial cell line(A549), human hepatoma cell line(HePG-2) and human colorectal cancer cell line(HCT116) treated by 30 nm Ps nanoparticles and Au-NPs.