Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus.
Lo VangChristopher S MorelloJason MendyDanielle ThompsonDarly ManayaniBen GuentherJustin JulanderDaniel SanfordAmit JainAmish PatelPaul ShabramJonathan SmithJeff AlexanderPublished in: PLoS neglected tropical diseases (2021)
These studies confirm that ZIKV VLPs could be efficiently generated and purified. Upon VLP immunization, in both mice and NHPs, nAb was induced that correlate with protection against ZIKV challenge. These studies support translational efforts in developing a ZIKV VLP vaccine for evaluation in human clinical trials.