Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure.
Eline L VegterEkaterina S OvchinnikovaHerman H W SilljéLaura M G MeemsAtze van der PolA Rogier van der VeldeEugene BerezikovAdriaan A VoorsRudolf A de BoerPeter Van der MeerPublished in: PloS one (2017)
The previous observation that miRNAs circulate in lower levels in human patients with heart failure could not be validated in well-established rat and mouse heart failure models. These results question the translation of data on human circulating miRNA levels to experimental models, and vice versa the validity of experimental miRNA data for human heart failure.