Discovery of Transacting Long Noncoding RNAs That Regulate Smooth Muscle Cell Phenotype.

Huitong ShiTrieu D NguyenQuanyi ZhaoPaul ChengVinod Scaria Hyun-Jung Kim Juyong Brian Kim Robert C Wirka Chad S WeldyJoão P MonteiroThomas Quertermous

Published in: Circulation research (2023)

Expression of a large and diverse set of lncRNAs in human coronary artery SMC are highly dynamic in response to CAD-related stimuli. The dynamic changes in expression of these lncRNAs correspond to alterations in transcriptional programs that are relevant to CAD, suggesting a critical role for lncRNAs in SMC phenotypic transition and human atherosclerotic disease.

Keyphrases

smooth muscle
endothelial cells
coronary artery
poor prognosis
coronary artery disease
induced pluripotent stem cells
small molecule
network analysis
gene expression
public health
pulmonary artery
binding protein
stem cells
genome wide analysis
long non coding rna
cell therapy