Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes.

Hyekyung YangDong Ho SuhDae Hee KimEun Sung JungKwang-Hyeon LiuChoong Hwan LeeCheol Young Park

Published in: British journal of pharmacology (2018)

Our results present evidence for the ameliorative effect of pioglitazone on hepatic steatosis, largely due to the regulation of lipid metabolism, including fatty acids, lysophosphatidylcholines, phosphatidylcholines and related gene-expression patterns.

Keyphrases

type diabetes
fatty acid
gene expression
dna methylation
adipose tissue
glycemic control
weight loss
metabolic syndrome
cardiovascular disease
insulin resistance
obese patients