Regulation of type I interferon: It's HIP to be K2.

Published in: Science signaling (2019)

Uncontrolled expression of type I interferon (IFN-I) drives autoimmunity, necessitating the need for tight regulation. In this issue, Cao et al reveal a role for the kinase HIPK2 in the transcriptional control of IFN-I during antiviral immune responses.

Keyphrases

dendritic cells
immune response
poor prognosis
gene expression
blood brain barrier
transcription factor
genome wide
single cell
toll like receptor
protein kinase
tyrosine kinase
oxidative stress
dna methylation
long non coding rna