Homeobox oncogene activation by pan-cancer DNA hypermethylation.

Jianzhong SuYung-Hsin HuangXiaodong CuiXinyu WangXiaotian ZhangYong LeiJianfeng XuXueqiu LinKaifu ChenJie LvMargaret A GoodellWeibo Xie

Published in: Genome biology (2018)

Our pan-cancer analysis followed by functional validation reveals DNA hypermethylation as a novel epigenetic mechanism for homeobox oncogene upregulation.

Keyphrases

papillary thyroid
circulating tumor
squamous cell
single molecule
cell free
gene expression
dna methylation
poor prognosis
squamous cell carcinoma
signaling pathway
young adults
nucleic acid