Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes.
Johanna SällAnnie M L PetterssonChristel BjörkEmma HenrikssonSebastian WasserstromWilhelm LinderYuedan ZhouOla HanssonDaniel P AnderssonMikael EkelundEva DegermanKarin G StenkulaJurga LaurencikieneOlga GöranssonPublished in: Diabetologia (2016)
This is the first study to describe the expression and function of SIKs in human adipocytes. Our data suggest that SIKs might be protective in the development of obesity-induced insulin resistance, with implications for future treatment strategies.
Keyphrases
- adipose tissue
- insulin resistance
- type diabetes
- endothelial cells
- high fat diet induced
- high fat diet
- metabolic syndrome
- glycemic control
- weight loss
- induced pluripotent stem cells
- polycystic ovary syndrome
- high glucose
- pluripotent stem cells
- blood glucose
- oxidative stress
- body mass index
- electronic health record
- data analysis