Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.

Zoé HanssSimone B LarsenPaul M A AntonyPauline MenckeFrançois MassartJavier JarazoJens Christian SchwambornPeter A BarbutiGeorge D MellickRejko Krüger

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

We describe for the first time the impact of the p.D620N VPS35 mutation on autophago-lysosome pathway and mitochondrial function in stem cell-derived neurons from an affected p.D620N carrier and define neuronal phenotypes for future pharmacological interventions. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

spinal cord
oxidative stress
physical activity
current status
fluorescent probe
living cells
randomized controlled trial
spinal cord injury
cerebral ischemia