Protective Effects of Imatinib on a DSS-induced Colitis Model Through Regulation of Apoptosis and Inflammation.

Hyeonjin KimChae Yeon KimDongwook KimEungyung KimLei MaKanghyun ParkZhibin LiuK E HuangWeihong WenJiwon KoSu-Geun LimYounghun SungZae Young RyooJun Koo YiSoyoung JangMyoung Ok Kim

Published in: In vivo (Athens, Greece) (2024)

Overall, imatinib treatment significantly alleviated the symptoms of DSS-induced colitis by influencing the expression of proinflammatory cytokines, tight junction proteins, and apoptotic markers in mice. These findings highlight imatinib as a potential therapeutic candidate for IBD.

Keyphrases

chronic myeloid leukemia
oxidative stress
cell death
poor prognosis
endoplasmic reticulum stress
cell cycle arrest
type diabetes
anti inflammatory
combination therapy
binding protein
cell proliferation
adipose tissue
ulcerative colitis