Reappraisal of psoriasis pathogenesis: the role of TEAD4 expression in keratinocytes.

Wafaa Ahmed ShehataMostafa A HammamAmani R ElbaklyNoha Elkady

Published in: International journal of dermatology (2024)

TEAD4 expression was higher in lesional than nonlesional skin and absent in healthy skin, suggesting a role in psoriasis development. TEAD4 expression was also associated with severe and progressive psoriasis. This may be mediated by the downregulation of FOXP3 and dysfunction of Treg cells. TEAD4 could serve as a promising therapeutic target in psoriasis.

Keyphrases

poor prognosis
binding protein
multiple sclerosis
atopic dermatitis
oxidative stress
soft tissue
regulatory t cells
cell proliferation
immune response
dendritic cells
drug induced