Pro-inflammatory adiponectin in pediatric-onset multiple sclerosis.
Mukanthu H NyirendaGiulia FaddaLuke M HealyIna MexhitajLaurence Poliquin-LasnierHeather HanwellAlexander W SaverianoAyal RozenbergRui LiCraig S MooreChahrazed BelabaniTrina JohnsonJulia O'MahonyDouglas L ArnoldE Ann YehKathryn C FitzgeraldShannon DunnBrenda BanwellAmit Bar-OrPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)
Elevated APN levels in children with MS may contribute to enhanced pro-inflammatory states of innate and adaptive peripheral immune responses and breach CNS-resident microglia quiescence, providing a plausible and potentially targetable mechanism by which APN contributes to MS disease activity.
Keyphrases
- multiple sclerosis
- disease activity
- immune response
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- mass spectrometry
- juvenile idiopathic arthritis
- ms ms
- white matter
- young adults
- metabolic syndrome
- inflammatory response
- dendritic cells
- toll like receptor
- blood brain barrier
- insulin resistance
- neuropathic pain
- type diabetes
- chemotherapy induced
- skeletal muscle