CD36 drives metastasis and relapse in acute myeloid leukemia.
Thomas FargeJean NakhleDamien LagardeGuillaume CognetNathaniel PolleyRémy CastellanoMarie-Laure NicolauClaudie BoscMarie SabatierAmbrine SahalEstelle SalandYannick JeansonNathan GuiraudEmeline BoetCamille BergoglioMathilde GotanègrePierre-Luc MouchelLucille StuaniClément LarrueMarie SalleseVéronique De MasCedric MoroCédric DrayYves ColletteIsabelle Raymond LetronIsabelle AderChristian RecherJean-Emmanuel SarryFlorence CabonFrançois VergezAudrey CarrièrePublished in: Cancer research (2023)
Identifying mechanisms underlying relapse is a major clinical issue for effective cancer treatment. The emerging understanding of the importance of metastasis in hematological malignancies suggests that it could also play a role in drug resistance and relapse in acute myeloid leukemia (AML). In a cohort of 1,273 AML patients, we uncovered that the multifunctional scavenger receptor CD36 was positively associated with extramedullary dissemination of leukemic blasts, increased risk of relapse after intensive chemotherapy, and reduced event-free and overall survival. CD36 was dispensable for lipid uptake but fostered blast migration through its binding with thrombospondin-1. CD36-expressing blasts, which were largely enriched after chemotherapy, exhibited a senescent-like phenotype while maintaining their migratory ability. In xenograft mouse models, CD36 inhibition reduced metastasis of blasts and prolonged survival of chemotherapy-treated mice. These results pave the way for the development of CD36 as an independent marker of poor prognosis in AML patients and a promising actionable target to improve the outcome of patients.