Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer.
Rodrigo Gularte-MéridaShaleigh SmithAnita S BowmanArnaud da Cruz PaulaWalid K ChatilaCraig M BielskiMonika VyasLaetitia BorsuAhmet ZehirLuciano G MartelottoJinru ShiaRona YaegerFang FangRui GardnerRuibang LuoMichael C SchatzRonglai ShenJorge S Reis-FilhoFrancisco Sánchez-VegaJorge Sergio Reis-FilhoJaclyn F HechtmanPublished in: JCO precision oncology (2022)
Our findings indicate that dual-driver mutations occur in a rare subset of CRC, often within the same tumor cells and across multiple tumor sites. Their presence and a lower rate of allelic imbalance may be related to dose-dependent signaling within the mitogen-activated protein kinase pathway.