Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI.

Francesca GuidaMonica IannottaAnna LauritanoRosmara InfantinoEmanuela SalviatiRoberta VerdeLivio LuongoEduardo Maria SommellaFabio Arturo IannottiPietro CampigliaSabatino MaioneVincenzo Di MarzoFabiana Piscitelli

Published in: Acta neuropathologica communications (2024)

Mild TBI induces biochemical changes in AD genetically predisposed mice and the eCBome may play a role in the pathogenetic link between brain injury and neurodegenerative disorders also by interacting with the serotonergic system.

Keyphrases

brain injury
cognitive impairment
subarachnoid hemorrhage
high fat diet induced
traumatic brain injury
mild traumatic brain injury
cerebral ischemia
cognitive decline
adipose tissue
protein kinase
wild type
mild cognitive impairment