RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12.
Heladia SalgadoSocorro Gama-CastroPaloma LaraCitlalli Mejia-AlmonteGabriel Alarcón-CarranzaAndrés G López-AlmazoFelipe Betancourt-FigueroaPablo Peña-LoredoShirley Alquicira-HernándezDaniela Ledezma-TejeidaLizeth Arizmendi-ZagalFrancisco Mendez-HernandezAna K Diaz-GomezElizabeth Ochoa-PraxedisLuis J Muñiz-RascadoJair S García-SoteloFanny A Flores-GallegosLaura GómezCésar Bonavides-MartínezVíctor M Del Moral-ChávezAlfredo J Hernández-AlvarezAlberto Santos-ZavaletaSalvador CapellaJosep Lluis GelpíJulio Collado-VidesPublished in: Nucleic acids research (2023)
RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput methodologies. Here, we describe biological advances since our last NAR paper of 2019. We explain the changes to satisfy FAIR requirements. We also present a full reconstruction of the RegulonDB computational infrastructure, which has significantly improved data storage, retrieval and accessibility and thus supports a more intuitive and user-friendly experience. The integration of graphical tools provides clear visual representations of genetic regulation data, facilitating data interpretation and knowledge integration. RegulonDB version 12.0 can be accessed at https://regulondb.ccg.unam.mx.