Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease.

Weichang ZhangLuis GonzalezXin LiHualong BaiZhuo LiRyosuke TaniguchiJohn LangfordYuichi OhashiCarly ThaxtonAoyagi YukihikoBogdan YatsulaKathleen A Martin Julie Elizabeth Goodwin George Tellides Xiaochun LongChang ShuAlan Dardik

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

CKD promotes EndMT and reduces AVF patency. Inhibition of TGF-β signaling, especially disruption of endothelial cell-specific TGF-β signaling, attenuates EndMT and improves AVF patency in mouse AVF. Inhibition of EndMT may be a therapeutic approach of translational significance to improve AVF patency in human patients with CKD.

Keyphrases

endothelial cells
chronic kidney disease
transforming growth factor
end stage renal disease
stem cells
high glucose
bone marrow
type diabetes
metabolic syndrome
skeletal muscle
induced pluripotent stem cells
high fat diet induced
pluripotent stem cells