Risk of acute liver injury associated with use of antibiotics. Comparative cohort and nested case-control studies using two primary care databases in Europe.

Ruth BrauerIan DouglasLuis Alberto Garcia RodriguezGerald DowneyConsuelo HuertaFrancisco de AbajoAndrew BateMaurille Feudjo TepieMark C H de GrootRaymond SchliengerRobert ReynoldsLiam SmeethOlaf KlungelAna Ruigómez

Published in: Pharmacoepidemiology and drug safety (2017)

Guided by a common protocol, both cohort and case-control study designs found an increased risk of ALI associated with the use of antibiotics in both databases, independent of the exposure and case definitions used. However, the magnitude of the risk was higher in CPRD compared to BIFAP.

Keyphrases

case control
liver injury
drug induced
primary care
randomized controlled trial
liver failure
big data
respiratory failure
machine learning
general practice
hepatitis b virus
mechanical ventilation