Biomarkers of intestinal barrier function in multiple sclerosis are associated with disease activity.
Carlos Rodrigo Cámara-LemarroyClaudia SilvaJamie GreenfieldWei-Qiao LiuLuanne M MetzV Wee YongPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
People with MS have altered biomarkers of intestinal barrier integrity. Zonulin concentrations are associated with 1-year disease progression in progressive MS and closely mirror BBB breakdown in RRMS. Zonulin may mediate breakdown of both the intestinal barrier and the BBB in gut dysbiosis through the regulation of tight junctions. This could explain how the gut-brain axis modulates neuroinflammation in MS.
Keyphrases
- multiple sclerosis
- disease activity
- blood brain barrier
- white matter
- mass spectrometry
- rheumatoid arthritis
- systemic lupus erythematosus
- ms ms
- rheumatoid arthritis patients
- cerebral ischemia
- ankylosing spondylitis
- traumatic brain injury
- resting state
- lipopolysaccharide induced
- functional connectivity
- single molecule