Obesity is a multi-factorial disease that is influenced by genetic, epigenetic, and environmental factors. Precision medicine is a practice wherein prevention and treatment strategies take individual variability into account. It involves using a variety of factors including deep phenotyping using clinical, physiologic, and behavioral characteristics, 'omics assays (eg, genomics, epigenomics, transcriptomics, and microbiomics among others), and environmental factors to devise practices that are individualized to subsets of patients. Personalizing the therapeutic modality to the individual can lead to enhanced effectiveness and tolerability. The authors review advances in precision medicine made in the field of bariatrics and discuss future avenues and challenges.
Keyphrases
- single cell
- primary care
- healthcare
- end stage renal disease
- high throughput
- weight loss
- ejection fraction
- metabolic syndrome
- randomized controlled trial
- chronic kidney disease
- type diabetes
- insulin resistance
- systematic review
- prognostic factors
- gene expression
- adipose tissue
- peripheral blood
- clinical trial
- weight gain
- roux en y gastric bypass
- current status
- quality improvement
- body mass index
- high fat diet induced
- skeletal muscle