Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2 H.
Jun YangShengqing ZhuFang WangFeng-Ling QingLingling ChuPublished in: Angewandte Chemie (International ed. in English) (2020)
A silver-mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF2 H is reported for the first time. This method enables direct and facile access to CF2 H-alkenes from abundant alkenes with excellent functional-group compatibility. Moreover, this Ag/TMSCF2 H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CF2 H bonds.