CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis.

Yuping DuXin LiuSong ZhangShuo ChenXue GuanQianhui LiXi ChenYang Zhao

Published in: Reproductive biology and endocrinology : RB&E (2021)

CircCRIM1 bond with miR-145-5p to work as competing endogenous RNA (ceRNA) of CRIM1, and circCRIM1 bond with miR-383-5p to improve the expression of ZEB2 in ovarian cancer. CircCRIM1 and CRIM1 promoted the ovarian cancer progression and supplied a novel insight into the researches of ovarian cancer.

Keyphrases

long non coding rna
epithelial mesenchymal transition
poor prognosis
signaling pathway
cancer therapy
binding protein