Study protocol on the role of intestinal microbiota in colorectal cancer treatment: a pathway to personalized medicine 2.0.

R AarnoutseJ M P G M de Vos-GeelenJ PendersE G BoermaF A R M WarmerdamB GoortsS W M Olde DaminkZ SoonsS S M RensenMarjolein L Smidt

Published in: International journal of colorectal disease (2017)

We aim to detect a microbiota composition that predicts if patients with metastatic and/or irresectable colorectal cancer will respond to systemic treatment and/or experience zero to limited chemotoxicity. If we are able to identify a favorable microbiota composition, fecal microbiota transplantation might be the low-burden alternative to chemotherapy switch in the future.

Keyphrases

study protocol
randomized controlled trial
clinical trial
squamous cell carcinoma
radiation therapy
combination therapy
open label
cell therapy
locally advanced
smoking cessation