Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study.
Nita G ForouhiFumiaki ImamuraStephen J SharpAlbert KoulmanMatthias B SchulzeJusheng ZhengZheng YeIvonne SluijsMarcela GuevaraJosé María Huerta CastañoJanine KrögerLaura Yun WangKeith SummerhillJulian L GriffinEdith J M FeskensAurélie AffretPilar AmianoHeiner BoeingCourtney DowGuy FagherazziPaul W FranksCarlos GonzalezRudolf KaaksTimothy J KeyKay Tee KhawTilman KühnLotte Maxild MortensenPeter M NilssonKim OvervadValeria PalaDomenico PalliSalvatore PanicoJ Ramón QuirósMiguel Rodríguez BarrancoOlov RolandssonCarlotta SacerdoteAugustin ScalbertNadia SlimaniAnnemieke M W SpijkermanAnne TjonnelandMaria-Jose TormoRosario TuminoDaphne L van der AYvonne T van der SchouwClaudia LangenbergElio RiboliNicholas J WarehamPublished in: PLoS medicine (2016)
These large-scale findings suggest an important inverse association of circulating plant-origin n-3 PUFA (ALA) but no convincing association of marine-derived n3 PUFAs (EPA and DHA) with T2D. Moreover, they highlight that the most abundant n6-PUFA (LA) is inversely associated with T2D. The detection of associations with previously less well-investigated PUFAs points to the importance of considering individual fatty acids rather than focusing on fatty acid class.