Mediation analysis with a time-to-event outcome: a review of use and reporting in healthcare research.
Lauren Lapointe-ShawZachary BouckNicholas A HowellTheis LangeAni Orchanian-CheffPeter C AustinNoah M IversDonald A RedelmeierChaim M BellPublished in: BMC medical research methodology (2018)
There is increasing use of mediation analysis with time-to-event outcomes. Current usage is limited by reliance on traditional methods and the Cox Proportional Hazards model, as well as low rates of reporting of underlying assumptions. There is a need for formal criteria to aid authors, reviewers, and readers reporting or appraising such studies.