Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the initial stage, which makes the majority of the treatment options largely unsuccessful and leads to extensive metastasis, as well as to its distinct pathophysiological characteristics, such as rich desmoplastic tumours bounded by dysplastic and hypo perfused vessels restricting the mobility of therapeutic agents. Continued attempts have been made to utilise innovative measures for battling PC to increase the therapeutic effectiveness of therapies and overcome their cytotoxicity. Combined cancer targeting and gene silencing approach has shown improved outcomes in patients' survival rates and quality of life, offering a potential solution to therapeutic complications. It particularly targets various barriers to alleviate delivery problems and diminish tumour recurrence and metastasis. While aptamers, a type of single-stranded nucleic acids with strong binding affinity and specificity to target molecules, have recently surfaced as a viable PC strategy, siRNA can interfere with the expression of certain genes. By concurrently suppressing genes and boosting targeted approach, the cocktail of siRNA/Aptamer and other therapeutic drugs can circumvent the multi-drug resistance phenomena. Additionally, combination therapy with additive or synergistic effects can considerably increase the therapeutic efficacy of anti-cancer medications. This study outlines the primary difficulties in treating PC, along with recent developments in siRNA/Aptamer mediated drug delivery to solve the major hiccup of oncology field.
Keyphrases
- cancer therapy
- poor prognosis
- drug delivery
- combination therapy
- long non coding rna
- gold nanoparticles
- end stage renal disease
- sensitive detection
- genome wide
- free survival
- binding protein
- newly diagnosed
- systematic review
- chronic kidney disease
- type diabetes
- squamous cell carcinoma
- signaling pathway
- ejection fraction
- magnetic nanoparticles
- papillary thyroid
- peritoneal dialysis
- bioinformatics analysis
- climate change
- adipose tissue
- metabolic syndrome
- weight loss
- young adults
- lymph node metastasis
- genome wide analysis
- childhood cancer