IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer.
Maria Cristina De MartinoPeter M van KoetsveldRichard A FeeldersWouter W de HerderFadime DoganJoseph A M J L JanssenDavine Hofste Op BruininkClaudia PivonelloA Marlijn WaaijersAnnamaria ColaoRonald R de KrijgerRosario PivonelloLeo J HoflandPublished in: Endocrine (2019)
In addition to IGF2 and IGF1R, ACC express IGF2R, IRA and several IGFBPs, suggesting that the interplay between the different components of the IGF pathway in ACC could be more complex than previously considered. The addition of mTOR inhibitors to linsitinib may have stronger antiproliferative effects than linsitinib alone.