Cp*Co(III)-Catalyzed Regioselective C2 Amidation of Indoles Using Acyl Azides.

A cobalt-catalyzed C2-selective amidation of indoles using acyl azides has been accomplished. Isotope experiments suggest that C-H activation is reversible. The use of sustainable Co catalysis, functional group diversity, substrate scope, and regioselectivity are the important practical features.