Aberrant tryptophan metabolism in stromal cells is associated with mesenteric fibrosis in small intestinal neuroendocrine tumors.

Anela Blažević Anand M Iyer Marie-Louise F Van VelthuysenJohannes HoflandPeter M van KoestveldGaston J H FranssenRichard A FeeldersMarina ZajecTheo M LuiderWouter W de HerderLeo J Hofland

Published in: Endocrine connections (2022)

We found a decreased expression of tryptophan and serotonin-metabolizing enzymes in the stroma in patients with MF, most notably in the mesenteric stroma. This might account for the increased profibrotic potential of serotonin and explain the variability in the development of SI-NET-associated fibrotic complications.

Keyphrases

neuroendocrine tumors
poor prognosis
systemic sclerosis
risk factors
idiopathic pulmonary fibrosis
binding protein
long non coding rna
climate change
ionic liquid